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New screening trial to save thousands of men’s lives from prostate cancer

By May 7, 2024No Comments

Thousands more men could be saved every year as a new screening trial aims to double the efficacy of prostate cancer screening.

The £42m trial called TRANSFORM aims to find the best way to screen men for prostate cancer and is co-funded by Prostate Cancer UK and NIHR.

The Government is investing £16m for the trial through NIHR. Movember is providing £1.5m funding, and there is support from the Freddie Green and Family Charitable Foundation.

Previous trials using the current blood tests PSA (prostate-specific antigen) and biopsy to screen for prostate cancer have shown it is possible to prevent 8% and 20% of prostate cancer deaths. This depends on how regularly men are screened. TRANSFORM will test new approaches which have the potential to more than double this impact and reduce prostate cancer deaths by 40%. With over 12,000 prostate cancer deaths in the UK, this could mean thousands of men saved each year here, and many thousands more worldwide.

TRANSFORM will bring together 6 of the world’s leading prostate cancer researchers. They will lead the team taking on the biggest prostate cancer screening trial for 20 years. It will begin recruitment of hundreds of thousands of men from across the UK next year.

Prostate Cancer UK worked with NIHR and the National Screening Committee to ensure the trial will provide the evidence needed to revolutionise prostate cancer diagnosis. It will compare multiple methods of screening. These will be compared against how men are tested now. They aim to find the safest, most accurate and most cost-effective way to screen men for prostate cancer.

The team will collect a biobank of samples, images and data at a scale never seen before in prostate cancer. This will be available to other cancer researchers. It is predicted to spur a wave of new discoveries and provide proof for the next generation of diagnostics.

The trial’s flexible design means promising new testing methods can be added at any stage.

TRANSFORM stage 1: Around 12,500 men

Researchers will compare 4 potential screening options. This includes:

  • PSA blood tests
  • faster versions of MRI scans (known as Prostagram)
  • genetic testing to identify those at higher risk

These new approaches will be compared to the current NHS diagnostic process. This will show which methods are most accurate and should be taken forward into the trial’s second stage. The first stage will take 3 years to complete. It will produce important results, especially about the accuracy of the diagnostic tests used in the NHS today. Those early results could start to impact the way men are tested for prostate cancer at that point.

TRANSFORM stage 2: Up to 300,000 men

Researchers will test the most promising options in a much bigger group of men. This will provide the definitive evidence for the best way to screen men for prostate cancer.

The team will follow hundreds of thousands of men over at least 10 years to track how the screening approaches impact them. This includes:

  • lives saved
  • harms associated with potentially unnecessary biopsies and treatment

Recruiting black men

1 in 4 Black men will develop prostate cancer – double the risk of other men. Therefore, to ensure the trial helps reduce their risk of dying from the disease, 1 in 10 of the men invited to participate will be Black men.

The NIHR funding is provided through the Health Technology Assessment (HTA) Programme. HTA has initially committed £4m for the trial’s pilot stage. Further funding will be provided for the main trial if the pilot is shown to be successful.

The study is also supported by the NIHR Clinical Research Network (CRN). More details are on the trial’s project page

Ben Kemp